Cdc7 kinase stimulates Aurora B kinase in M-phase
نویسندگان
چکیده
منابع مشابه
RNA Stimulates Aurora B Kinase Activity during Mitosis
Accurate chromosome segregation is essential for cell viability. The mitotic spindle is crucial for chromosome segregation, but much remains unknown about factors that regulate spindle assembly. Recent work implicates RNA in promoting proper spindle assembly independently of mRNA translation; however, the mechanism by which RNA performs this function is currently unknown. Here, we show that RNA...
متن کاملAurora B kinase, an immobile passenger!
Aurora kinase phosphorylates microtubule binding factors, decreases their affinity for microtubules, and in turn, spindle microtubules are destabilized around kinetochores. The main Aurora B substrates involved in this dynamic are Ndc80/Hec1, a subunit of the Kinetochore-Microtubule-Network (KMN), and the microtubule-destabilizing factors MCAK and Stathmin/OP18. In the past, the main question w...
متن کاملElucidating the roles of Aurora B kinase in neurons
To reveal molecular determinates that underlie the intrinsic molecular pathways within neurons that support regeneration after injury, a DNA microarray study was performed on axotomized neuronal clusters that were maintained in culture and free from glial and astrocytes contamination. The microarray data indicated that post-injury regenerative sprouting requires two distinct pathways; a cell su...
متن کاملLAB-1 antagonizes the Aurora B kinase in C. elegans.
The Shugoshin/Aurora circuitry that controls the timely release of cohesins from sister chromatids in meiosis and mitosis is widely conserved among eukaryotes, although little is known about its function in organisms whose chromosomes lack a localized centromere. Here we show that Caenorhabditis elegans chromosomes rely on an alternative mechanism to protect meiotic cohesin that is shugoshin-in...
متن کاملSelective Disruption of Aurora C Kinase Reveals Distinct Functions from Aurora B Kinase during Meiosis in Mouse Oocytes
Aurora B kinase (AURKB) is the catalytic subunit of the chromosomal passenger complex (CPC), an essential regulator of chromosome segregation. In mitosis, the CPC is required to regulate kinetochore microtubule (K-MT) attachments, the spindle assembly checkpoint, and cytokinesis. Germ cells express an AURKB homolog, AURKC, which can also function in the CPC. Separation of AURKB and AURKC functi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-54738-2